Deebo Samuel (groin) officially ruled out for Week 13.

This was expected with Samuel considered week-to-week, and hopefully he can be back in either Week 14 or Week 15. San Francisco will rely on Brandon Aiyuk to step up as their No. 1 wide receiver against Seattle, and he should be started as a high-upside WR2 option.

12/3/21 - 04:40 PM ET

Trey Sermon (ankle) ruled out for Week 13.

Sermon was carted off last week, so it’s a good sign that the injury isn’t serious enough to have already been placed on injured reserve—though Kyle Shanahan has said it’s a possibility. Jeff Wilson Jr. will remain the clear No. 2 runner behind workhorse Elijah Mitchell on Sunday.

12/3/21 - 04:38 PM ET

Melvin Gordon (hip) is doubtful for Week 13.

Gordon was called 50-50 yesterday, and that was a sign he’d be leaning towards not playing, so now fantasy owners should definitely prepare to be without him this week. Javonte Williams will be the clear lead back against the Chiefs on Sunday night and needs to be started as an upside RB2. Mike Boone should also see some work behind the rookie.

12/3/21 - 03:20 PM ET

Odell Beckham Jr. (hip) is questionable for Sunday.

The expectation is that Beckham will be ready to go for Sunday against the Jaguars, but this might come down to how he’s feeling during pregame warmups. If you’re planning to use OBJ in Week 13 fantasy lineups, just be sure to have a backup plan in mind from the later games.

12/3/21 - 02:36 PM ET

Darrell Henderson Jr. (thigh) is questionable for Week 13.

Henderson is set to be a game-time call, and the Rams play in the later slate of games on Sunday, so this might create a tough situation for fantasy owners. Hopefully there’s more clarity on Henderson’s status by Sunday morning.

12/3/21 - 02:34 PM ET