The 2025 NFL season is set to commence in September. However, before the new season gets underway, top sports betting sites have revealed odds for a vast array of futures, including who’s most likely to be crowned Offensive Player of the Year (OPOY).
Ride along as we run you through the OPOY odds at some of the best bookies in the United States. These odds reflect the performances of different players in the previous NFL season. You can expect them to fluctuate depending on how the upcoming season progresses.
Who’s most likely to win the OPOY award in 2026?
So many players could be contending for the OPOY award when the 2025 NFL season concludes, but leading the charts is running back Saquon Barkley.
During an historic 2024 season, Barkley scored 13 touchdowns in 16 appearances. He also had a total of 345 carries for 2,005 yards. These numbers led him to his first-ever Offensive Player of the Year trophy capped by a Super Bowl victory in his first year with the Philadelphia Eagles. And the odds are in favor of him doing it for a second consecutive season.
Saquon Barkley leads the lines at sportsbooks such as BetMGM and FanDuel. BetMGM opens him at +500, while FanDuel highlights him as the top bet with odds of +550. Barkley ranking as the No. 1 player to get the OPOY award stems from his stellar form and the fact that the Eagles retain most of their offensive core from last season—including an elite offensive line returning four starters.
Who’s behind Saquon Barkley?
Coming in behind Barkley is an array of wide receivers and running backs. Here’s an overview of the top 10 players in contention:
| Player Name | BetMGM OPOY Odds | FanDuel OPOY Odds |
| Saquon Barkley | +500 | +550 |
| Ja’Marr Chase | +1000 | +900 |
| Jahmyr Gibbs | +1000 | +1300 |
| Bijan Robinson | +1200 | +1800 |
| Derrick Henry | +1400 | +1400 |
| Justin Jefferson | +1600 | +1400 |
| Puka Nacua | +1600 | +1600 |
| CeeDee Lamb | +1800 | +2000 |
| Christian McCaffrey | +1800 | +2000 |
| Nico Collins | +1800 | +1600 |
Betting tips to make smart OPOY wagers
Platforms like SportyTrader have become popular among bettors for delivering the latest NFL betting picks and predictions across popular markets. Here are a couple of simple tips that may also come in handy when placing your OPOY wagers:
Avoid short odds before the season starts
Saquon Barkley ranks as the offensive player with the highest chances of winning the OPOY at +500 and +550. However, these odds are the lowest for this market, reflecting the athlete’s elite status. Since upsets and injuries can shift a team’s form very quickly, it’s not very profitable to take short odds this early.
Watch and see if the player‘s production remains strong, and you can still back him, if at slightly lower odds. But at least you have more information to justify your betting on short odds.
Consider other players regardless of bookie rankings
While Barkley is the favorite to win the OPOY award for next season, there are plenty of offensive stars across the league. Other running backs such as Bijan Robinson and Derrick Henry are the go-to for many bettors due to their running instincts, versatility, and explosiveness in a game where running the ball is in vogue again. Both have much higher odds, so backing them can lead to a huge payout if they end up winning the award.
With the 2025 NFL season less than two months away, US sportsbooks are locking in lines on potential Offensive Player of the Year winners. The Eagles’ Saquon Barkley leads the charts, but other stars like third-year back Bijan Robinson and fellow former 2,000-yard rusher Derrick Henry remain squarely in the preseason discussion.